Anti-Certolizumab ELISA Kit (AF879038)

개요
이미지
참고 문헌
데이터시트

개요

카탈로그 번호	AF879038
설명	Anti-Certolizumab ELISA Kit (AF879038) — Quantitative sandwich ELISA for Anti-Certolizumab. Sample: Plasma, Serum. Range: 156.25 - 10, 000 ng/mL. Highlights ●Sandwich Format — High specificity, reliable quantification. ●Ready-to-Use — Complete kit with pre-coated plates included.
샘플 유형	Plasma, Serum
범위	156.25 - 10, 000 ng/mL
등록번호	P01375
응용 분야	ELISA
검출 방법	Colorimetric
분석 유형	Quantitative
회수율	80-120%
배송	2-8 ℃
안정성 및 저장	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
사양	Certolizumab
대체 이름	CDP870, PHA-738144, Certolizumab pegol, 428863-50-7
배경	Tumor necrosis factor (Certolizumab) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. 1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208 2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952 3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918 4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
참고사항	For Research Use Only.