Anti-Adalimumab Neutralizing Antibody ELISA kit (AF879048)

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Numéro de catalogue	AF879048
Description	Anti-Adalimumab Neutralizing Antibody ELISA kit (AF879048) — Quantitative competitive ELISA for Anti-Adalimumab Neutralizing Antibody. Sample: Plasma, Serum. Range: 15.625-1, 000 ng/ml. Highlights ●Competitive Format — High specificity, reliable quantification. ●Ready-to-Use — Complete kit with pre-coated plates included.
Type d'échantillon	Plasma, Serum
Sensibilité	10.94 ng/ml
Plage	31.25-2000 ng/ml
Numéro d'accès	P01375
Applications	ELISA
Méthode de détection	Colorimetric
Type de test	Quantitative
Retraitement	80-120%
Expédition	2-8 ℃
Stabilité et stockage	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Spécifications	Adalimumab
Noms alternatifs	ABP 501, D2E7, Adalimumab, 331731-18-1
Contexte	Tumor necrosis factor (Adalimumab) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. 1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208 2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952 3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918 4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
Note	For Research Use Only.