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| カタログ番号 | HV592014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD321/F11R Polyclonal Antibody (HV592014) is a rabbit polyclonal antibody detecting CD321 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD321/F11R (Phe64-Leu249). | ||||||||
| ターゲット | PAM-1, JAM1, Platelet F11 receptor, JCAM, JAM-A, F11R, Junctional adhesion molecule A, Junctional adhesion molecule 1, CD321, Platelet adhesion molecule 1, JAM-1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y624 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Junctional adhesion molecule A (CD321/F11R) is a ~32 kDa protein. Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. 1. Itoh, M. et al. (2001) The Journal of cell biology 154, 491-7. PMID: 11489913 2. Ostermann, G. et al. (2002) Nature immunology 3, 151-8. PMID: 11812992 3. Sobocka, MB. et al. (2000) Blood 95, 2600-9. PMID: 10753840 | ||||||||
| 注意事項 | For research use only. |
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