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| カタログ番号 | HY307014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD55 Polyclonal Antibody (HY307014) is a rabbit polyclonal antibody detecting CD55 in ELISA, IHC, WB. Suitable for Human and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD55 (Asp35-Gly285). | ||||||||
| ターゲット | Complement decay-accelerating factor, CR, DAF, CD55 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08174 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complement decay-accelerating factor (CD55) is a ~41 kDa protein. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. 1. Ward, T. et al. (1994) The EMBO journal 13, 5070-4. PMID: 7525274 2. Ozen, A. et al. (2017) The New England journal of medicine 377, 52-61. PMID: 28657829 | ||||||||
| 注意事項 | For research use only. |
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