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Anti-Human CD55/DAF Recombinant Antibody (TS55) (HY307107)

Anti-Human CD55/DAF Recombinant Antibody (TS55)
Anti-Human CD55/DAF Recombinant Antibody (TS55)
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Overview
Catalog No.HY307107
Species reactivityHuman
ApplicationsFCM
Host speciesMouse
IsotypeIgG1, kappa
Clone IDTS55
Clonality Monoclonal
Target Complement decay-accelerating factor, CR, DAF, CD55
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P08174
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background

Complement decay-accelerating factor (CD55) is a ~41 kDa protein. This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage.

1. Ward, T. et al. (1994) The EMBO journal 13, 5070-4. PMID: 7525274
2. Ozen, A. et al. (2017) The New England journal of medicine 377, 52-61. PMID: 28657829
Note For research use only.
Images
  • Anti-Human CD55/DAF Recombinant Antibody (TS55)

    SDS-PAGE

    SDS-PAGE for Anti-Human CD55 Antibody (TS55)

References
Formula
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