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| カタログ番号 | HC299014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD94/KLRD1 Polyclonal Antibody (HC299014) is a rabbit polyclonal antibody detecting KLRD1 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, Pan troglodytes, and Pongo pygmaeus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD94/KLRD1 (Lys32-Ile179). | ||||||||
| ターゲット | Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13241 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Natural killer cells antigen CD94 (KLRD1) is a ~20 kDa protein. Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal. 1. Boyington, JC. et al. (1999) Immunity 10, 75-82. PMID: 10023772 2. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301 3. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576 4. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229 5. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650 6. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572 7. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742 8. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220 | ||||||||
| 注意事項 | For research use only. |
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