Anti-Human CD94 Reference Antibody (Dibotatug, RUO) (HC299016)

Name: Anti-Human CD94 Reference Antibody (Dibotatug, RUO)
Brand: abinScience
SKU: HC299016
Price: 336 USD
Availability: InStock

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Overview

Catalog No.	HC299016
Description	Dibotatug (HC299016) is a research-grade recombinant antibody targeting CD94. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13241
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2842038-48-4
Background	Natural killer cells antigen CD94 (KLRD1) is a ~20 kDa protein. Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal. 1. Boyington, JC. et al. (1999) Immunity 10, 75-82. PMID: 10023772 2. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301 3. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576 4. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229 5. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650 6. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572 7. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742 8. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Dibotatug.
Bioactivity

Detects recombinant CD94 (Catalog No: HC299012) in indirect ELISA.

References

Datasheet

Anti-Human CD94 Reference Antibody (Dibotatug, RUO).pdf

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Anti-Human CD94 Reference Antibody (Dibotatug, RUO) (HC299016)

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