Anti-CD94/KLRD1 Polyclonal Antibody (HC299014)

Name: Anti-CD94/KLRD1 Polyclonal Antibody
Brand: abinScience
SKU: HC299014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HC299014

Description

Anti-CD94/KLRD1 Polyclonal Antibody (HC299014) is a rabbit polyclonal antibody detecting KLRD1 in ELISA, IHC, WB. Suitable for Human, Macaca mulatta, Pan troglodytes, and Pongo pygmaeus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD94/KLRD1 (Lys32-Ile179).

Target

Killer cell lectin-like receptor subfamily D member 1, NK cell receptor, Natural killer cells antigen CD94, CD94, KP43, KLRD1

Purification

Purified by antigen affinity column.

Accession

Q13241

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Natural killer cells antigen CD94 (KLRD1) is a ~20 kDa protein. Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.

1. Boyington, JC. et al. (1999) Immunity 10, 75-82. PMID: 10023772

2. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301

3. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576

4. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229

5. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650

6. Llano, M. et al. (1998) European journal of immunology 28, 2854-63. PMID: 9754572

7. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742

8. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220

Note

For research use only.

Images

References

Datasheet

Anti-CD94/KLRD1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CD94/KLRD1 Polyclonal Antibody (HC299014)

Overview

Images

References

Datasheet

SDS

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