Anti-Human ANO1 Monoclonal Antibody (1A608) (HP641035)

Name: Anti-Human ANO1 Monoclonal Antibody (1A608)
Brand: abinScience
SKU: HP641035
Price: 106 USD
Availability: InStock

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Каталожный номер	HP641035
Описание	Anti-Human ANO1 Monoclonal Antibody (1A608) [1A608] (HP641035) is a mouse monoclonal antibody detecting ANO1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG
ID клона	1A608
Иммуноген	E. coli - derived recombinant human ANO1 (Met117-Gly325).
Цель	Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q5XXA6
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Anoctamin-1 (ANO1) is a ~114 kDa protein. Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. 1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604 2. Ousingsawat, J. et al. (2011) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 28, 715-24. PMID: 22178883 3. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059 4. Park, JH. et al. (2021) Journal of medical genetics 58, 247-253. PMID: 32487539 5. Benedetto, R. et al. (2017) Scientific reports 7, 12397. PMID: 28963502 6. Cabrita, I. et al. (2021) American journal of respiratory cell and molecular biology 64, 50-58. PMID: 33026825 7. Simões, FB. et al. (2019) Life science alliance 2. PMID: 31732694
Примечание	For research use only.