Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

Name: Anti-Human C9orf72 Recombinant Antibody (SAA1886)
Brand: abinScience
SKU: HA376013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HA376013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1886

Cible

Guanine nucleotide exchange C9orf72, C9orf72

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q96LT7

RRID

Anti-Human C9orf72 Antibody (SAA1886) (abinScience Cat# HA376013, RRID:AB_3727650)
_x005F_x005F_x000D_

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro.

1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190

3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292

4. Jung, J. et al. (2017) eLife 6. PMID: 28195531

5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human C9orf72 Antibody (SAA1886)

Reférences

Fiche technique

Anti-Human C9orf72 Recombinant Antibody (SAA1886).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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