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| カタログ番号 | HA376013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1886 | ||||
| ターゲット | Guanine nucleotide exchange C9orf72, C9orf72 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q96LT7 | ||||
| RRID | Anti-Human C9orf72 Antibody (SAA1886) (abinScience Cat# HA376013, RRID:AB_3727650) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190 3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292 4. Jung, J. et al. (2017) eLife 6. PMID: 28195531 5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human C9orf72 Antibody (SAA1886)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
