

| Каталожный номер | HX243137 |
|---|---|
| Реактивность видов | Human |
| Применения | FCM |
| Хозяинский вид | Mouse |
| Клоональность | Monoclonal |
| Изотип | IgG1, kappa |
| ID клона | SAA0047 |
| Конъюгация | APC |
| Цель | IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Связанные продукты | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| Номер доступа | Q01344 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Фон | Interleukin-5 receptor subunit alpha (CD125/IL5RA) is a ~47 kDa protein. Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. 1. Monahan, J. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 4024-34. PMID: 9378992 2. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999 3. Kusano, S. et al. (2012) Protein science : a publication of the Protein Society 21, 850-64. PMID: 22528658 4. Ogata, N. et al. (1998) Blood 91, 2264-71. PMID: 9516124 |
| Примечание | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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