Anti-Human IL-5 R alpha/CD125 Reference Antibody (Benralizumab, RUO) (HX243016)

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100ug
1mg

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Overview

Catalog No.	HX243016
Description	Benralizumab (HX243016) is a research-grade recombinant antibody targeting CD125. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01344
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BIW-8405, KHK4563, MEDI-563, 1044511-01-4
Background	Interleukin-5 receptor subunit alpha (CD125/IL5RA) is a ~47 kDa protein. Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. 1. Monahan, J. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 159, 4024-34. PMID: 9378992 2. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999 3. Kusano, S. et al. (2012) Protein science : a publication of the Protein Society 21, 850-64. PMID: 22528658 4. Ogata, N. et al. (1998) Blood 91, 2264-71. PMID: 9516124
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Benralizumab.
SEC-HPLC

SEC-HPLC detection for Research Grade Benralizumab.
Bioactivity

Detects Human CD125/IL5RA in indirect ELISAs.

References

HX243016-SDS-PAGE-1.jpg

Datasheet

Anti-Human IL-5 R alpha/CD125 Reference Antibody (Benralizumab, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Human IL-5 R alpha/CD125 Reference Antibody (Benralizumab, RUO) (HX243016)

Overview

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References

Datasheet

SDS

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