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| カタログ番号 | HT182137 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | 11G2 |
| 抱合 | APC |
| ターゲット | ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| アクセッション番号 | O14672 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~84 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). 1. Lemjabbar, H. et al. (2002) Nature medicine 8, 41-6. PMID: 11786905 2. Gutwein, P. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 292-4. PMID: 12475894 3. Rabquer, BJ. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 1777-85. PMID: 20592283 4. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 5. Jouannet, S. et al. (2016) Cellular and molecular life sciences : CMLS 73, 1895-915. PMID: 26686862 6. Reyat, JS. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 666-676. PMID: 28600292 7. Eschenbrenner, E. et al. (2020) Life science alliance 3. PMID: 31792032 8. Lipper, CH. et al. (2022) Structure (London, England : 1993) 30, 206-214.e4. PMID: 34739841 9. Lipper, CH. et al. (2023) Cell 186, 3632-3641.e10. PMID: 37516108 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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