

| Каталожный номер | HV234014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014) is a rabbit polyclonal antibody detecting CD169/SIGLEC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CD169/SIGLEC1 (Gly34-Gly240). | ||||||||
| Цель | Siglec-1, CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9BZZ2 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis. 1. Jones, C. et al. (2003) Molecular microbiology 49, 1213-25. PMID: 12940982 2. Benet, S. et al. (2021) Journal of extracellular vesicles 10, e12046. PMID: 33489013 3. Hammonds, JE. et al. (2017) PLoS pathogens 13, e1006181. PMID: 28129379 4. Perez-Zsolt, D. et al. (2021) Cellular & molecular immunology 18, 2676-2678. PMID: 34782760 5. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190 | ||||||||
| Примечание | For research use only. |



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