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Human CD169/SIGLEC1 Recombinant Protein (C-His) (HV234011)

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Overview

Catalog No.	HV234011
Description	Recombinant Human CD169/SIGLEC1 Protein, C-His (HV234011) expressed in Mammalian Cells, spanning Met1-Gln1641. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian Cells
Accession	Q9BZZ2
Protein length	Met1-Gln1641
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin, Siglec-1
Background	Sialoadhesin is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis. 1. Jones, C. et al. (2003) Molecular microbiology 49, 1213-25. PMID: 12940982 2. Benet, S. et al. (2021) Journal of extracellular vesicles 10, e12046. PMID: 33489013 3. Hammonds, JE. et al. (2017) PLoS pathogens 13, e1006181. PMID: 28129379 4. Perez-Zsolt, D. et al. (2021) Cellular & molecular immunology 18, 2676-2678. PMID: 34782760 5. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190
Note	For research use only

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Datasheet

Human CD169/SIGLEC1 Recombinant Protein (C-His).pdf

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Formula

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Human CD169/SIGLEC1 Recombinant Protein (C-His)