Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye) (HB856107)

Name: Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye)
Brand: abinScience
SKU: HB856107
Price: 191 USD
Availability: InStock

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Обзор

Каталожный номер	HB856107
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	U3-17846J6Ye
Цель	FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P22455
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Примечание	For research use only.

Изображения

Bioactivity

Detects CD334/FGFR4 in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD334/FGFR4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD334/FGFR4 (Catalog No: HB856011)
Lane 2: negative control

Ссылки

Даташит

Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye).pdf

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Formula

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