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Anti-Human CD334/FGFR4 Recombinant Antibody (U3-17846J6Ye), FITC (HB856117)

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Overview

Catalog No.	HB856117
Description	Anti-Human CD334/FGFR4 Antibody (U3-17846J6Ye), FITC [U3-17846J6Ye] (HB856117) is a mouse monoclonal antibody detecting FGFR4 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	U3-17846J6Ye
Conjugation	FITC
Clonality	Monoclonal
Target	FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334
Endotoxin level	Please contact with the lab for this information.
Accession	P22455
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD334/FGFR4 Recombinant Antibody (U3-17846J6Ye), FITC.pdf

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Anti-Human CD334/FGFR4 Recombinant Antibody (U3-17846J6Ye), FITC