Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye) (HB856107)

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Overview

Catalog No.	HB856107
Description	Anti-Human CD334/FGFR4 Antibody (U3-17846J6Ye) [U3-17846J6Ye] (HB856107) is a human monoclonal antibody detecting FGFR4 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG1, kappa
Clone ID	U3-17846J6Ye
Clonality	Monoclonal
Target	FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P22455
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Note	For research use only.

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Bioactivity

Detects CD334/FGFR4 in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD334/FGFR4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD334/FGFR4 (Catalog No: HB856011)
Lane 2: negative control

References

Datasheet

Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye).pdf

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Anti-Human FGFR4 Recombinant Antibody (U3-17846J6Ye) (HB856107)

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