Anti-Human FGFR4 Reference Antibody (U3-1784, RUO) (HB856016)

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Overview

Catalog No.	HB856016
Description	Anti-Human CD334/FGFR4 (U3-1784) (HB856016) is a research-grade recombinant antibody targeting CD334. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	U3-1784
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	FGFR4, Fibroblast growth factor receptor 4, TKF, FGFR-4, JTK2, CD334
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P22455
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	U3-1784
Background	Fibroblast growth factor receptor 4 (CD334/FGFR4) is a ~87 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD334/FGFR4 (U3-1784)

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Anti-Human FGFR4 Reference Antibody (U3-1784, RUO).pdf

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Anti-Human FGFR4 Reference Antibody (U3-1784, RUO) (HB856016)

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