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Anti-Human CEACAM6/CD66c Recombinant Antibody (SAA0029), APC (HW494137)

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概要
カタログ番号HW494137
種反応性Human
アプリケーションFCM
宿主種Human
クローン性Monoclonal
アイソタイプIgG1, kappa
クローンIDSAA0029
抱合APC
ターゲット Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen
エンドトキシンレベル Please contact with the lab for this information.
関連製品 Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
アクセッション番号 P40199
形態 Liquid
保存バッファー 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

安定性と保存 Store at 4°C for 12 months. Protect from light. Do not freeze.
背景

Cell adhesion molecule CEACAM6 (CD66c) is a ~37 kDa protein. Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells.

1. Ordoñez, C. et al. (2000) Cancer research 60, 3419-24. PMID: 10910050
2. Kuroki, M. et al. (2001) Journal of leukocyte biology 70, 543-50. PMID: 11590190
3. Kuijpers, TW. et al. (1992) The Journal of cell biology 118, 457-66. PMID: 1378450
4. Blumenthal, RD. et al. (2005) Cancer research 65, 8809-17. PMID: 16204051
5. Oikawa, S. et al. (1991) The Journal of biological chemistry 266, 7995-8001. PMID: 2022629
6. Oikawa, S. et al. (1989) Biochemical and biophysical research communications 164, 39-45. PMID: 2803308
7. Yamanaka, T. et al. (1996) Protein expression and purification 7, 438-46. PMID: 8776764
注意事項 For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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