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Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO) (HW494026)

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Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO)

Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO)

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Spec:

100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HW494026
Description	Lemalesomab (HW494026) is a research-grade recombinant antibody targeting CD66. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG1-nd
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40199
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	78NCA-90, IMMU-MN3, 250242-54-7
Background	Cell adhesion molecule CEACAM6 (CD66c) is a ~37 kDa protein. Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. 1. Ordoñez, C. et al. (2000) Cancer research 60, 3419-24. PMID: 10910050 2. Kuroki, M. et al. (2001) Journal of leukocyte biology 70, 543-50. PMID: 11590190 3. Kuijpers, TW. et al. (1992) The Journal of cell biology 118, 457-66. PMID: 1378450 4. Blumenthal, RD. et al. (2005) Cancer research 65, 8809-17. PMID: 16204051 5. Oikawa, S. et al. (1991) The Journal of biological chemistry 266, 7995-8001. PMID: 2022629 6. Oikawa, S. et al. (1989) Biochemical and biophysical research communications 164, 39-45. PMID: 2803308 7. Yamanaka, T. et al. (1996) Protein expression and purification 7, 438-46. PMID: 8776764
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

SEC-HPLC detection for Research Grade Lemalesomab.
SDS-PAGE

SDS-PAGE for Research Grade Lemalesomab.

References

Datasheet

Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO).pdf

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Anti-Human CEACAM-5/CD66e Reference Antibody (Lemalesomab, RUO)