Anti-Human CEACAM-5/CD66e Reference Antibody (Sulesomab, RUO) (HW494036)

Name: Anti-Human CEACAM-5/CD66e Reference Antibody (Sulesomab, RUO)
Brand: abinScience
SKU: HW494036
Price: 176 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HW494036
Description	Sulesomab (HW494036) is a research-grade recombinant antibody targeting CD66. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG1, kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Normal cross-reacting antigen, Carcinoembryonic antigen-related cell adhesion molecule 6, CEACAM6, CD66c, NCA, Non-specific crossreacting antigen
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40199
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	IMMU-MN3, Technetium(99mTc)sulesomab, LeukoScan, 167747-19-5
Background	Cell adhesion molecule CEACAM6 (CD66c) is a ~37 kDa protein. Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 occurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells. 1. Ordoñez, C. et al. (2000) Cancer research 60, 3419-24. PMID: 10910050 2. Kuroki, M. et al. (2001) Journal of leukocyte biology 70, 543-50. PMID: 11590190 3. Kuijpers, TW. et al. (1992) The Journal of cell biology 118, 457-66. PMID: 1378450 4. Blumenthal, RD. et al. (2005) Cancer research 65, 8809-17. PMID: 16204051 5. Oikawa, S. et al. (1991) The Journal of biological chemistry 266, 7995-8001. PMID: 2022629 6. Oikawa, S. et al. (1989) Biochemical and biophysical research communications 164, 39-45. PMID: 2803308 7. Yamanaka, T. et al. (1996) Protein expression and purification 7, 438-46. PMID: 8776764
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CEACAM-5/CD66e Reference Antibody (Sulesomab, RUO)
Flow cytometry

Flow-cytometry using APC anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using PE anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry using FITC anti-human CD66c antibody. BXPC-3 cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD66c monoclonal antibody (Catalog HW494036, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, and cells analysed on a NovoCyte Flow Cytometer.