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Anti-Human Factor X Recombinant Antibody (SAA2441) (HF610023)

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Anti-Human Factor X Recombinant Antibody (SAA2441)
Anti-Human Factor X Recombinant Antibody (SAA2441)
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  • 1mg
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Vista general
Número de catálogoHF610023
Descripción
Anti-Human Factor X Recombinant Antibody (SAA2441) (HF610023) is a human monoclonal antibody detecting Factor X in ELISA, Bioactivity: FCM, Functional assay, Research in vivo. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG4, kappa
ID de clonSAA2441
Objetivo Coagulation factor X, EC:3.4.21.6, Stuart factor, Stuart-Prower factor, Factor X light chain, Factor X heavy chain, Activated factor Xa heavy chain, F10
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P00742
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:2000-1:20000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Coagulation factor X (F10) is a ~54 kDa protein. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner. Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues.

1. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427
2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037
3. Bukowska, A. et al. (2013) European journal of pharmacology 718, 114-23. PMID: 24041930
4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593
5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181
6. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198
7. Shrivastava, G. et al. (2022) ImmunoHorizons 6, 373-383. PMID: 35738824
8. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208
Nota For research use only.
Isotype Control Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
Imágenes
  • Anti-Human Factor X Recombinant Antibody (SAA2441)

    SDS-PAGE

    SDS-PAGE for Anti-Human F10/Factor X Antibody (SAA2441)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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