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Anti-Human Guanylyl Cyclase C/GUCY2C Recombinant Nanobody (SAA2687) (HB626023)

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  • 1mg
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Vista general
Número de catálogoHB626023
Descripción
Anti-Human GUCY2C Nanobody (SAA2687) [SAA2687] (HB626023) is a alpaca monoclonal antibody detecting GUCY2C in ELISA. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA
Especie huéspedAlpaca
ClonalidadMonoclonal
IsotipoVHH-8His
ID de clonSAA2687
Objetivo EC:4.6.1.2, GC-C, GUC2C, GUCY2C, Guanylyl cyclase C, Heat-stable enterotoxin receptor, Intestinal guanylate cyclase, STA receptor, STAR, hSTAR
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by Nickel column.
Número de acceso P25092
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Guanylyl cyclase C (GUCY2C) is a ~123 kDa protein. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.

1. Scott, RO. et al. (2002) The Journal of biological chemistry 277, 22934-41. PMID: 11950846
2. Singh, S. et al. (1991) Biochemical and biophysical research communications 179, 1455-63. PMID: 1718270
3. Fiskerstrand, T. et al. (2012) The New England journal of medicine 366, 1586-95. PMID: 22436048
4. Romi, H. et al. (2012) American journal of human genetics 90, 893-9. PMID: 22521417
5. Arshad, N. et al. (2013) The Journal of biological chemistry 288, 3907-17. PMID: 23269669
6. de Sauvage, FJ. et al. (1991) The Journal of biological chemistry 266, 17912-8. PMID: 1680854
7. Mann, EA. et al. (1993) The American journal of physiology 264, G172-8. PMID: 8381596
Nota For research use only.
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Referencias
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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