Anti-Human GUCY2C Recombinant Antibody (SAA0124), FITC (HB626117)

Name: Anti-Human GUCY2C Recombinant Antibody (SAA0124), FITC
Brand: abinScience
SKU: HB626117
Price: 223 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.	HB626117
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG1, kappa
Clone ID	SAA0124
Conjugation	FITC
Clonality	Monoclonal
Target	STAR, Intestinal guanylate cyclase, GC-C, GUC2C, STA receptor, Heat-stable enterotoxin receptor, Guanylyl cyclase C, hSTAR, GUCY2C
Endotoxin level	Please contact with the lab for this information.
Accession	P25092
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Guanylyl cyclase C (GUCY2C/GCC) is a ~123 kDa protein. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. 1. Scott, RO. et al. (2002) The Journal of biological chemistry 277, 22934-41. PMID: 11950846 2. Singh, S. et al. (1991) Biochemical and biophysical research communications 179, 1455-63. PMID: 1718270 3. Fiskerstrand, T. et al. (2012) The New England journal of medicine 366, 1586-95. PMID: 22436048 4. Romi, H. et al. (2012) American journal of human genetics 90, 893-9. PMID: 22521417 5. Arshad, N. et al. (2013) The Journal of biological chemistry 288, 3907-17. PMID: 23269669 6. de Sauvage, FJ. et al. (1991) The Journal of biological chemistry 266, 17912-8. PMID: 1680854 7. Mann, EA. et al. (1993) The American journal of physiology 264, G172-8. PMID: 8381596
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow cytometry

Flow cytometry analysis was performed using anti-human GUCY2C monoclonal antibody. CHO cells transiently transfected with human GUCY2C plasmids were incubated with an irrelevant antibody (blue histogram) or FITC-conjugated anti-human GUCY2C monoclonal antibody (Catalog # HB626117, green histogram) at a concentration of 5 µg/mL for 30 min at room temperature. After washing, cells were directly analyzed on a NovoCyte Flow Cytometer.

References

Datasheet