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| カタログ番号 | HT363013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1954 | ||||
| ターゲット | Hypocretin receptor type 1, Ox1-R, Ox1R, Ox-1-R, Orexin receptor type 1, HCRTR1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O43613 | ||||
| RRID | Anti-Human HCRTR1/OX1R Antibody (SAA1954) (abinScience Cat# HT363013, RRID:AB_3727718) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Orexin/Hypocretin receptor type 1 (HCRTR1/OX1R) is a ~47 kDa protein. G-protein coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization. Plays a significant role in the regulation of food intake. 1. Hellmann, J. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 18059-18067. PMID: 32669442 2. Sakurai, T. et al. (1998) Cell 92, 573-85. PMID: 9491897 3. Milasta, S. et al. (2005) The Biochemical journal 387, 573-84. PMID: 15683363 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human HCRTR1/OX1R Antibody (SAA1954)
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