Human HCRTR1 Recombinant Protein (N-GST & C-His) (HT363022)

Name: Human HCRTR1 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HT363022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HT363022
Description	Recombinant Human HCRTR1 Protein, N-GST & C-His (HT363022) expressed in E. coli, spanning Gln179-Lys213. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O43613
Protein length	Gln179-Lys213
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	32.20 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HCRTR1, Hypocretin receptor type 1, Orexin receptor type 1, Orexin/Hypocretin receptor type 1, Ox-1-R, Ox1-R, Ox1R
Background	Orexin/Hypocretin receptor type 1 is a ~47 kDa protein. G-protein coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization. Plays a significant role in the regulation of food intake. 1. Hellmann, J. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 18059-18067. PMID: 32669442 2. Sakurai, T. et al. (1998) Cell 92, 573-85. PMID: 9491897 3. Milasta, S. et al. (2005) The Biochemical journal 387, 573-84. PMID: 15683363
Note	For research use only

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Datasheet

Human HCRTR1 Recombinant Protein (N-GST & C-His).pdf

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Human HCRTR1 Recombinant Protein (N-GST & C-His) (HT363022)

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