中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HF832024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human HEXIM1 Polyclonal Antibody (HF832024) is a rabbit polyclonal antibody detecting HEXIM1 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Bovine, Mus musculus, and Human.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HEXIM1 (Thr171-Asp359). | ||||||||
| ターゲット | HEXIM1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O94992 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1 | ||||||||
| 背景 | Protein HEXIM1 is a ~40 kDa protein. Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. 1. Yik, JH. et al. (2003) Molecular cell 12, 971-82. PMID: 14580347 2. Michels, AA. et al. (2004) The EMBO journal 23, 2608-19. PMID: 15201869 3. Yik, JH. et al. (2005) The Journal of biological chemistry 280, 16368-76. PMID: 15713661 4. Michels, AA. et al. (2003) Molecular and cellular biology 23, 4859-69. PMID: 12832472 5. Wittmann, BM. et al. (2005) Oncogene 24, 5576-88. PMID: 15940264 6. Shimizu, N. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8555-60. PMID: 15941832 7. Kohoutek, J. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 17349-54. PMID: 17088550 8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-HEXIM1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
