Human HEXIM1 Recombinant Protein (N-GST & C-His) (HF832032)

Name: Human HEXIM1 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HF832032
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF832032
Description	Recombinant Human HEXIM1 Protein, N-GST & C-His (HF832032) expressed in E. coli, spanning Asp258-Asp359. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O94992
Protein length	Asp258-Asp359
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	40.45 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CLP1, Cardiac lineage protein 1, EDG1, Estrogen down-regulated gene 1 protein, HEXIM1, HIS1, Hexamethylene bis-acetamide-inducible protein 1, MAQ1, Menage a quatre protein 1, Protein HEXIM1
Background	Protein HEXIM1 is a ~40 kDa protein. Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. 1. Yik, JH. et al. (2003) Molecular cell 12, 971-82. PMID: 14580347 2. Michels, AA. et al. (2004) The EMBO journal 23, 2608-19. PMID: 15201869 3. Yik, JH. et al. (2005) The Journal of biological chemistry 280, 16368-76. PMID: 15713661 4. Michels, AA. et al. (2003) Molecular and cellular biology 23, 4859-69. PMID: 12832472 5. Wittmann, BM. et al. (2005) Oncogene 24, 5576-88. PMID: 15940264 6. Shimizu, N. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8555-60. PMID: 15941832 7. Kohoutek, J. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 17349-54. PMID: 17088550 8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728
Note	For research use only