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Anti-Human LINGO1 Recombinant Antibody (SAA0824), APC (HV367137)

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Vista general
Número de catálogoHV367137
Reactividad de especiesHuman
AplicacionesELISA, FCM
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG1, kappa
ID de clonSAA0824
ConjugaciónAPC
Objetivo LRRN6A, LERN1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, LINGO1, Leucine-rich repeat neuronal protein 6A, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Nivel de endotoxinas Please contact with the lab for this information.
Productos asociados Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Número de acceso Q96FE5
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Estabilidad y almacenamiento Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) is a ~69 kDa protein. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

1. Mi, S. et al. (2004) Nature neuroscience 7, 221-8. PMID: 14966521
2. Park, JB. et al. (2005) Neuron 45, 345-51. PMID: 15694321
3. Mi, S. et al. (2005) Nature neuroscience 8, 745-51. PMID: 15895088
Nota For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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C₂ (Working Conc.)
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