Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO) (HV367016)

Name: Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO)
Brand: abinScience
SKU: HV367016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV367016
Description	Opicinumab (HV367016) is a research-grade recombinant antibody targeting LRRN6A. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	LRRN6A, LERN1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat and immunoglobulin domain-containing protein 1, LINGO1, Leucine-rich repeat neuronal protein 6A, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q96FE5
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BIIB-033, 1422268-07-2
Background	Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) is a ~69 kDa protein. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 1. Mi, S. et al. (2004) Nature neuroscience 7, 221-8. PMID: 14966521 2. Park, JB. et al. (2005) Neuron 45, 345-51. PMID: 15694321 3. Mi, S. et al. (2005) Nature neuroscience 8, 745-51. PMID: 15895088
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Opicinumab.
SDS-PAGE

SDS-PAGE for Research Grade Opicinumab.

References

Datasheet

Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO).pdf

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Anti-Human LINGO1 Reference Antibody (Opicinumab, RUO) (HV367016)

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