Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), FITC (HC513117)

Name: Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), FITC
Brand: abinScience
SKU: HC513117
Price: 223 USD
Availability: InStock

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Numéro de catalogue	HC513117
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG2, kappa
ID de clone	SAA0143
Conjugaison	FITC
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), FITC
Numéro d'accès	Q04721, Q9UM47
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Simpson, MA. et al. (2011) Nature genetics 43, 303-5. PMID: 21378985 2. Isidor, B. et al. (2011) Nature genetics 43, 306-8. PMID: 21378989 3. Fukushima, H. et al. (2017) Molecular cell 68, 645-658.e5. PMID: 29149593 4. Zhu, P. et al. (2015) Nature communications 6, 7122. PMID: 25985737
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human Notch-2/Notch-3 Recombinant Antibody (SAA0143), FITC.pdf

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