Anti-Human NOTCH2/3 Recombinant Antibody (SAA0143), APC (HC513137)

Name: Anti-Human NOTCH2/3 Recombinant Antibody (SAA0143), APC
Brand: abinScience
SKU: HC513137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HC513137
Species reactivity	Human
Applications	FCM
Host species	Human
Isotype	IgG2, kappa
Clone ID	SAA0143
Conjugation	APC
Clonality	Monoclonal
Endotoxin level	Please contact with the lab for this information.
Associated products	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10), APC
Accession	Q04721, Q9UM47
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Simpson, MA. et al. (2011) Nature genetics 43, 303-5. PMID: 21378985 2. Isidor, B. et al. (2011) Nature genetics 43, 306-8. PMID: 21378989 3. Fukushima, H. et al. (2017) Molecular cell 68, 645-658.e5. PMID: 29149593 4. Zhu, P. et al. (2015) Nature communications 6, 7122. PMID: 25985737
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human NOTCH2/3 Recombinant Antibody (SAA0143), APC.pdf

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Anti-Human NOTCH2/3 Recombinant Antibody (SAA0143), APC (HC513137)

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