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Anti-Human PMEL17/ME20M Recombinant Antibody (SAA2599) (HW380023)

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Aperçu
Numéro de catalogueHW380023
Reactivité des espècesHuman
ApplicationsELISA, FCM, IHC
Espèce hôteMouse
ClonalitéMonoclonal
IsotypeIgG2a, kappa
ID de cloneSAA2599
Cible 95 kDa melanocyte-specific secreted glycoprotein, D12S53E, M-alpha, M-beta, ME20-M, ME20-S, ME20M, ME20S, Melanocyte protein PMEL, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, P26, PMEL, PMEL17, Premelanosome protein, SILV, Secreted melanoma-associated ME20 antigen, Silver locus protein homolog
Niveau d'endotoxines Please contact with the lab for this information.
Pureté >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Numéro d'accès P40967
Forme Liquid
Tampon de stockage 0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:2000-1:20000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Melanocyte protein PMEL (PMEL17/ME20M) is a ~70 kDa protein. Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.

Note For research use only
Isotype Control Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)
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Formula
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