Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9) (HW380107)

Name: Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9)
Brand: abinScience
SKU: HW380107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW380107
Species reactivity	Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Applications	ELISA, FCM, IHC
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	17A9
Clonality	Monoclonal
Target	ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40967
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Melanocyte protein PMEL (PMEL17/ME20M) is a ~70 kDa protein. Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
Note	For research use only.

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Western blot

Western blot analysis was performed using anti-PMEL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human PMEL (Catalog No: HW380012)
Lane 2: negative control
Bioactivity

Detects recombinant human PMEL (Catalog No: HW380012) in indirect ELISA

References

Datasheet

Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9).pdf

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Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9) (HW380107)

Overview

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References

Datasheet

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