Mouse Anti-Human PMEL17/ME20M Antibody (17A9), FITC (HW380117)

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Overview

Catalog No.	HW380117
Description	Mouse Anti-Human PMEL17/ME20M Antibody (17A9), FITC [17A9] (HW380117) is a mouse monoclonal antibody detecting ME20M in ELISA, FCM. Suitable for Human, Mouse, Rat, and Monkey. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows. ●Multi-Species — Cross-reactive for translational research.
Species reactivity	Human, Mouse, Rat, Monkey
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	17A9
Conjugation	FITC
Clonality	Monoclonal
Target	ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
Endotoxin level	Please contact with the lab for this information.
Accession	P40967
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Melanocyte protein PMEL (PMEL17/ME20M) is a ~70 kDa protein. Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Mouse Anti-Human PMEL17/ME20M Antibody (17A9), FITC.pdf

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Mouse Anti-Human PMEL17/ME20M Antibody (17A9), FITC (HW380117)

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