Anti-Human PSEN2/Presenilin-2 Monoclonal Antibody (1A531) (HW821035)

Name: Anti-Human PSEN2/Presenilin-2 Monoclonal Antibody (1A531)
Brand: abinScience
SKU: HW821035
Price: 106 USD
Availability: InStock

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Каталожный номер	HW821035
Описание	Anti-Human PSEN2 Monoclonal Antibody (1A531) [1A531] (HW821035) is a mouse monoclonal antibody detecting PSEN2 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG
ID клона	1A531
Иммуноген	E. coli - derived recombinant human PSEN2 (Lys271-Lys361).
Цель	Presenilin-2, PS-2, EC:3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P49810
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. 1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236 2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302 3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394 4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189 5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978 6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576 7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369
Примечание	For research use only.

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Anti-Human PSEN2/Presenilin-2 Monoclonal Antibody (1A531).pdf

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Anti-Human PSEN2/Presenilin-2 Monoclonal Antibody (1A531) (HW821035)

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