Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033) (HC445053)

Name: Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033)
Brand: abinScience
SKU: HC445053
Price: 110 USD
Availability: InStock

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20ug
50ug
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1mg

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC445053

Reactivité des espèces

Human

Applications

ELISA, WB

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a

ID de clone

SAA2033

Cible

Phospho-TDP43 (Ser403, Ser404), pTDP43(403/404), phospho TDP-43 (Ser409/Ser410)

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q13148

RRID

Anti-Human pTDP43(Ser403/Ser404) Antibody (SAA2033) (abinScience Cat# HC445053, RRID:AB_3728959)
_x005F_x005F_x000D_

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

TAR DNA-binding protein 43 (pTARDBP/pTDP43) is a ~44 kDa protein. RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.

1. Bhardwaj, A. et al. (2013) Nucleic acids research 41, 5062-74. PMID: 23519609

2. Lukavsky, PJ. et al. (2013) Nature structural & molecular biology 20, 1443-9. PMID: 24240615

3. Kuo, PH. et al. (2014) Nucleic acids research 42, 4712-22. PMID: 24464995

4. Tollervey, JR. et al. (2011) Nature neuroscience 14, 452-8. PMID: 21358640

5. Wang, A. et al. (2018) The EMBO journal 37. PMID: 29438978

6. Izumikawa, K. et al. (2017) Scientific reports 7, 7709. PMID: 28794432

7. Fukushima, M. et al. (2019) FEBS letters 593, 277-287. PMID: 30520513

8. Colombrita, C. et al. (2009) Journal of neurochemistry 111, 1051-61. PMID: 19765185

9. Higashi, S. et al. (2013) Journal of neurochemistry 126, 288-300. PMID: 23398327

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human pTDP43(Ser403/Ser404) Antibody (SAA2033).

Reférences

Fiche technique

Anti-Human pTDP43(Ser403/Ser404) Recombinant Antibody (SAA2033).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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