Anti-Human ROBO1 Polyclonal Antibody (HP485014)

Name: Anti-Human ROBO1 Polyclonal Antibody
Brand: abinScience
SKU: HP485014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

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Vista general

Número de catálogo

HP485014

Descripción

Anti-Human ROBO1 Polyclonal Antibody (HP485014) is a rabbit polyclonal antibody detecting ROBO1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ROBO1 (Arg69-Ala166).

Objetivo

H-Robo-1, DUTT1, Roundabout homolog 1, Deleted in U twenty twenty, ROBO1

Purificación

Purified by antigen affinity column.

Número de acceso

Q9Y6N7

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Roundabout homolog 1 (ROBO1) is a ~180 kDa protein. Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.

1. Brose, K. et al. (1999) Cell 96, 795-806. PMID: 10102268

2. Leyva-Díaz, E. et al. (2014) Current biology : CB 24, 494-508. PMID: 24560577

3. Kong, R. et al. (2015) The Journal of clinical investigation 125, 4407-20. PMID: 26529257

Nota

For research use only.

Imágenes

Referencias

Datasheet