Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853) (HA089013)

Name: Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853)
Brand: abinScience
SKU: HA089013
Price: 196 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HA089013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

SAA1853

Objetivo

Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2

Nivel de endotoxinas

< 10 EU/mg

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

Q6UXX9

RRID

Anti-Human RSPO2 Antibody (SAA1853) (abinScience Cat# HA089013, RRID:AB_3727616)
_x005F_x000D_

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.

1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895

2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076

3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920

4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human RSPO2 Antibody (SAA1853)

Referencias

Datasheet

Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo