Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L6) (HA089023)

Name: Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L6)
Brand: abinScience
SKU: HA089023
Price: 126 USD
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Overview

Catalog No.	HA089023
Description	Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L6) (HA089023) is a mouse monoclonal antibody detecting R-Spondin 2 in Blocking, in vitro, in vivo, SPR. Suitable for Human, Mouse. Highlights ●Affinity Purified — Minimal background and high purity for reliable results. ●Multi-Application — Validated across multiple applications. ●Multi-Species — Cross-reactive for translational research.
Species reactivity	Human, Mouse
Applications	Blocking, in vitro, in vivo, SPR
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2a, kappa
Clone ID	h130M23-H1L6
Target	Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q6UXX9
RRID	Anti-Human RSPO2 Recombinant Antibody (h130M23-H1L6) (abinScience Cat# HA089023, RRID:AB_3729849)
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form. 1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895 2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076 3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920 4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720
Note	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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SDS-PAGE for Anti-Human RSPO2 Recombinant Antibody (h130M23-H1L6)

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Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L6).pdf

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Anti-Human R-Spondin 2 Recombinant Antibody (h130M23-H1L6) (HA089023)

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