Anti-Human RSPO2 Polyclonal Antibody (HA089014)

Name: Anti-Human RSPO2 Polyclonal Antibody
Brand: abinScience
SKU: HA089014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HA089014

Description

Anti-Human RSPO2 Polyclonal Antibody (HA089014) is a rabbit polyclonal antibody detecting RSPO2. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RSPO2 (Ser36-Gln243).

Target

R-spondin-2, RSPO2, Roof plate-specific spondin-2, hRspo2

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q6UXX9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.

1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895

2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076

3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920

4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720

Note

For research use only

Images

References

Datasheet

Anti-Human RSPO2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-Human RSPO2 Polyclonal Antibody (HA089014)

Overview

Images

References

Datasheet

SDS

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