Anti-Human RSPO2 Recombinant Antibody (SAA1853) (HA089013)

Name: Anti-Human RSPO2 Recombinant Antibody (SAA1853)
Brand: abinScience
SKU: HA089013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA089013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1853

Clonality

Monoclonal

Target

Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6UXX9

RRID

Anti-Human RSPO2 Antibody (SAA1853) (abinScience Cat# HA089013, RRID:AB_3727616)
_x005F_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.

1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895

2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076

3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920

4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human RSPO2 Antibody (SAA1853)

References

Datasheet

Anti-Human RSPO2 Recombinant Antibody (SAA1853).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human RSPO2 Recombinant Antibody (SAA1853) (HA089013)

Overview

Images

References

Datasheet

SDS

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