Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853) (HA089013)

Name: Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853)
Brand: abinScience
SKU: HA089013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HA089013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1853

Cible

Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q6UXX9

RRID

Anti-Human RSPO2 Antibody (SAA1853) (abinScience Cat# HA089013, RRID:AB_3727616)
_x005F_x000D_

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.

1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895

2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076

3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920

4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human RSPO2 Antibody (SAA1853)

Reférences

Fiche technique

Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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