Anti-Human SCN2B Recombinant Antibody (SAA1523) (HF959013)

Name: Anti-Human SCN2B Recombinant Antibody (SAA1523)
Brand: abinScience
SKU: HF959013
Price: 196 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HF959013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1523

Cible

SCN2B, Sodium channel subunit beta-2

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

O60939

RRID

Anti-Human SCN2B Antibody (SAA1523) (abinScience Cat# HF959013, RRID:AB_3727284)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels.

1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477

2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163

3. Das, S. et al. (2016) eLife 5. PMID: 26894959

4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605

5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606

6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491

7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human SCN2B Antibody (SAA1523)

Reférences

Fiche technique

Anti-Human SCN2B Recombinant Antibody (SAA1523).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai