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Anti-Human SCN2B Polyclonal Antibody (HF959014)

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Overview
Catalog No.HF959014
Description
Anti-Human SCN2B Polyclonal Antibody (HF959014) is a rabbit polyclonal antibody detecting SCN2B in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SCN2B (Met30-Ala159).
Target Sodium channel subunit beta-2, SCN2B, UNQ326/PRO386
Purification Purified by antigen affinity column.
Accession O60939
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels.

1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477
2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163
3. Das, S. et al. (2016) eLife 5. PMID: 26894959
4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605
5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606
6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491
7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-Human SCN2B Polyclonal Antibody

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