Human SCN2B Recombinant Protein (N-His) (HF959012)

Name: Human SCN2B Recombinant Protein (N-His)
Brand: abinScience
SKU: HF959012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF959012
Description	Recombinant Human SCN2B Protein, N-His (HF959012) expressed in E. coli, spanning Met30-Ala159. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O60939
Protein length	Met30-Ala159
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	17.19 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Sodium channel subunit beta-2, SCN2B, UNQ326/PRO386
Background	Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. 1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477 2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163 3. Das, S. et al. (2016) eLife 5. PMID: 26894959 4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605 5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606 6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491 7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201
Note	For research use only.

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SDS-PAGE for Recombinant Human SCN2B Protein, N-His

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Datasheet

Human SCN2B Recombinant Protein (N-His).pdf

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Human SCN2B Recombinant Protein (N-His) (HF959012)

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