Anti-Human SCN2B Recombinant Antibody (SAA1523) (HF959013)

Name: Anti-Human SCN2B Recombinant Antibody (SAA1523)
Brand: abinScience
SKU: HF959013
Price: 196 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD): --

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF959013

Description

Anti-Human SCN2B Recombinant Antibody (SAA1523) (HF959013) is a mouse monoclonal antibody detecting SCN2B in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a, kappa

Clone ID

SAA1523

Target

SCN2B, Sodium channel subunit beta-2

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O60939

RRID

Anti-Human SCN2B Antibody (SAA1523) (abinScience Cat# HF959013, RRID:AB_3727284)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels.

1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477

2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163

3. Das, S. et al. (2016) eLife 5. PMID: 26894959

4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605

5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606

6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491

7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human SCN2B Antibody (SAA1523)

References

Datasheet

Anti-Human SCN2B Recombinant Antibody (SAA1523).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SCN2B Recombinant Antibody (SAA1523) (HF959013)

Overview

Images

References

Datasheet

SDS