Anti-Human TLR5 Polyclonal Antibody (HT266014)

Name: Anti-Human TLR5 Polyclonal Antibody
Brand: abinScience
SKU: HT266014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HT266014

Description

Anti-Human TLR5 Polyclonal Antibody (HT266014) is a rabbit polyclonal antibody detecting CD285/TLR5 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human TLR5 (Ile21-Phe115).

Cible

TIL3, TLR5, Toll/interleukin-1 receptor-like protein 3, Toll-like receptor 5

Purification

Purified by antigen affinity column.

Numéro d'accès

O60602

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Toll-like receptor 5 (CD285/TLR5) is a ~97 kDa protein. Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.

1. Hayashi, F. et al. (2001) Nature 410, 1099-103. PMID: 11323673

2. Blohmke, CJ. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 7764-73. PMID: 18490781

3. Bielaszewska, M. et al. (2018) International journal of medical microbiology : IJMM 308, 882-889. PMID: 29934223

4. Gewirtz, AT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 1882-5. PMID: 11489966

5. Choi, YJ. et al. (2010) The Journal of biological chemistry 285, 37570-8. PMID: 20855887

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human TLR5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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